Figure 1.

Phenotype and somatic variant status of our retrospective RUNX1-FPD cohort. Distri-bution of phenotypic subgroups within the retrospective RUNX1-FPD cohort including ratios of cases with somatic RUNX1 variants and ratios of other acquired variants. AML—acute myeloid leukemia, HM—hematologic malignancies, MDS—myelodysplastic syndrome, MDS/AML—patients who developed myelodysplastic syndrome and subsequently acute myeloid leukemia, non-HM—cases without reported hematologic malignancies, RUNX1-FPD—familial platelet disorder with predisposition to hematologic malignancies.