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. 2022 Jul 14;14(14):3431. doi: 10.3390/cancers14143431

Figure 2.

Figure 2

RUNX1 germline variants in the retrospective RUNX1-FPD cohort. Schematic visualization of germline RUNX1 variants included in the retrospective RUNX1-FPD cohort including variant type and patients’ phenotype. Nomenclature refers to transcript variant 1 (NM_001754.4) encoding for isoform RUNX1c. AML—acute myeloid leukemia, HM—hematologic malignancies, MDS—myelodysplastic syndrome, MDS/AML—patients who developed MDS and subsequently AML, RHD—runt-homology domain, RUNX1-FPD—familial platelet disorder with predisposition to hematologic malignancies, TAD—transactivation domain.