Figure 3.

Frequently investigated and affected genes within the subgroup non-hematologic malignancy. Illustration of age, phenotype, type of RUNX1 germline variant and analyzed somatic variants for 30 non-HM cases. For references to the individual patients please refer to the supplementary data. AML—acute myeloid leukemia, HM—hematologic malignancies, MDS—myelodysplastic syndrome, MDS/AML—patients who developed MDS and subsequently AML, NA—not available, RUNX1-FPD—familial platelet disorder with predisposition to hematologic malignancies * some authors refer to the age of first reported symptoms and others to the age of genetic diagnosis.