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Central steroid allopregnanolone (ng/g) among young adult and middle-aged HIV-1 Tat-transgenic male mice [Tat(+)] or their non-Tat-expressing age-matched counterparts [Tat(−)]. (A) Hippocampal, (B) midbrain, and (C) frontal cortex allopregnanolone (alloP). *main effect for Tat(−) mice to differ from Tat(−) controls. †main effect for middle-aged mice to differ from young adults. ‡indicated group differs from all other groups, (two-way ANOVA, p < 0.05).
