Table 2. Simple linear regressions between circulating or central steroid hormones and behavioral assessments among HIV-1 Tat transgenic [Tat(+)] young adult and middle-aged male mice and age-matched non-Tat-expressing controls [Tat(−)].

Dependent Variable	Independent Variable	β	t-value (df)	r	R2	F-value (df)	p-value
Open field
Center time	Corticosterone	40.34	2.41 (23)	−0.46	0.21	5.82 (1,23)	0.025
	Frontal cortex alloP	57.21	3.29 (23)	−0.57	0.33	10.80 (1,23)	0.003
Center entries	Progesterone	11.31	2.65 (26)	0.47	0.22	7.00 (1,26)	0.01
	Hippocampal alloP	15.64	2.34 (20)	−0.47	0.22	5.50 (1,20)	0.031
	Frontal cortex alloP	13.84	2.06 (22)	−0.41	0.17	4.23 (1,22)	0.05
Velocity	Progesterone	4.54	2.24 (27)	−0.40	0.16	5.01 (1,27)	0.03
Distance	Progesterone	1360.40	2.25 (27)	−0.40	0.16	5.05 (1,27)	0.03
Elevated plus maze
Latency to open arm	Corticosterone	−58.35	5.72 (24)	−0.76	0.58	32.74 (1,25)	<0.0001
	Hippocampal alloP	−126.87	3.89 (24)	0.62	0.39	15.12 (1,25)	0.001
	Midbrain alloP	−63.86	2.87 (26)	0.49	0.24	8.24 (1,27)	0.01
	Frontal cortex alloP	−66.32	2.47 (26)	0.44	0.20	6.12 (1,27)	0.02
% Open arm time	Testosterone	3.35	2.10 (25)	0.38	0.15	4.29 (1,26)	0.05
RAWM
Reference memory error	Estradiol	5.10	2.56 (24)	0.29	0.08	6.53 (1,74)	0.013
Velocity	Progesterone	7.52	4.72 (28)	0.46	0.21	22.23 (1,86)	<0.0001
	Estradiol	8.12	3.74 (24)	0.40	0.16	14.00 (1,74)	0.0004
	Hippocampal alloP	6.30	3.26 (23)	0.35	0.12	10.65 (1,77)	0.002
	Testosterone	8.26	3.10 (25)	0.33	0.11	9.61 (1,80)	0.003
	Corticosterone	8.01	2.47 (24)	0.28	0.08	6.12 (1,74)	0.02
Distance	Testosterone	365.30	2.11 (24)	0.23	0.05	4.44 (1,80)	0.04
Grip strength
% forelimbs alone	Progesterone	1.33	2.04 (26)	−0.37	0.14	4.17 (1,27)	0.05
% Forelimbs and hindlimbs together	Corticosterone	1.82	−2.03 (21)	−0.41	0.17	4.14 (1,22)	0.05
Nociceptive-like behavior
Thermal hyperalgesia	Hippocampal alloP	42.89	2.54 (23)	0.47	0.22	6.45 (1,24)	0.02
Body and Organs Weight
Brain weight (%)	Testosterone	1.43	2.23 (24)	0.41	0.17	5.00 (1,25)	0.04