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. 2022 Jun 23;14(7):1372. doi: 10.3390/v14071372

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Combinational effects of CDK4/6 inhibitor PD-0332991 and PI3K inhibitor BYL719 (A) and PD-0332991 and FGFR inhibitor JNJ-42756493 (B) after 48 h. Combination indexes (CIs) were shown with the highest single agent approach after 48 h (A,B) and 72 h, where CI > 1 shows a negative combination effect and CI < 1 shows a positive combination effect. CIs were calculated from the mean of three experiments analyzed by WST-1, at 48 h after treatment. CI denotes combinational index; PD denotes PD-0332991; BYL denotes BYL719; and JNJ denotes JNJ-42756493.