Table 1.
ABC proteins involved in the transport of common antitumor drugs used in the treatment of hepatobiliary, pancreatic, and gastrointestinal tumors.
| Pharmacological Groups | Drugs | Cancers | ABC Pumps | ||
|---|---|---|---|---|---|
| Alkylating Drugs | Cyclophosphamide | HB | MRP1, 4 | ||
| Anthracyclines | Doxorubicin | GAC, HB, HCC | MDR1 | MRP1, 2, 6 | BCRP |
| Camptothecins | Irinotecan | BTC, CRC, GAC, HB, PDAC | MDR1 | MRP1, 2, 4, 6 | BCRP |
| TKIs | Sorafenib | HCC | MDR1 | MRP1, 2, 3 | BCRP |
| Regorafenib | CRC, HCC | MDR1 | MRP2 | ||
| Lenvatinib | HCC | MDR1 | MRP2 | ||
| Cabozantinib | HCC | MDR1 | MRP2 | ||
| Platinum Derivatives | Cisplatin | BTC, GAC, HB, HCC | MRP2, 6 | ||
| Oxaliplatin | BTC, CRC, GAC, PDAC | MRP2, 6 | |||
| Podophyllotoxins | Etoposide | BTC, HB | MDR1 | MRP1, 2 | |
| Pyrimidines | 5-FU | BTC, CRC, GAC, HB, HCC, PDAC | MRP1, 4, 5 | BCRP | |
| Gemcitabine | BTC, PDAC | MDR1 | MRP2, 4, 5, 6 | ||
| Taxanes | Docetaxel | GAC | MDR1 | MRP1 | |
| Vinca Alkaloids | Vinblastine | HB | MDR1 | MRP1, 2 | |
5-FU, 5-Fluorouracil; BCRP, breast cancer resistance protein; BTC, biliary tract cancer; CRC, colorectal carcinoma; GAC, gastric adenocarcinoma; HB, hepatoblastoma; HCC, hepatocellular carcinoma; MDR, multidrug resistance protein; MRP, multidrug resistant-associated protein; PDCA, pancreatic ductal adenocarcinoma; TKI, tyrosine kinase inhibitor.