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. 2022 Jul 6;14(14):3305. doi: 10.3390/cancers14143305

Figure 1.

Figure 1

Interaction between estrogen receptor (ER) and human epidermal growth factor -2 (HER2) pathways. In ER+/HER2+ tumors, the hyperactivation of HER2 signaling activates downstream kinases and downregulates ER expression, not only at the protein level but also at mRNA expression. EGFR: epidermal growth factor receptor; HER3: human epidermal growth factor -3; HER4: human epidermal growth factor -4; P: phosphorylated; MAPK: mitogen-activated protein kinase; PI3K: phosphoinositide-3-kinase; CoA: coactivator; G-protein: Guanine nucleotide binding protein; AKT: protein kinase B; SRC: steroid receptor coactivator. (Adapted from “HER2 Signaling Pathway”, by BioRender.com (2022). Retrieved from https://app.biorender.com/biorender-templates, accessed on 1 July 2022).