Table 3.
MR analysis results of diverse fatty acids (FAs) and Ulcerative colitis (UC).
| Fat Acids (Exposure) | MR Method | No. SNP | β | SE | OR(95%CI) | p |
|---|---|---|---|---|---|---|
| total FA | MR Egger | 14 | −0.051 | 0.602 | 0.951 (0.292, 3.091) | 0.934 |
| Weighted median | −0.196 | 0.294 | 0.822 (0.462, 1.462) | 0.505 | ||
| IVW(fixed effects) | −0.353 | 0.215 | 0.703 (0.461, 1.071) | 0.101 | ||
| Maximum likelihood | −0.355 | 0.218 | 0.701 (0.457, 1.075) | 0.103 | ||
| Penalised weighted median | −0.189 | 0.306 | 0.827 (0.455, 1.506) | 0.535 | ||
| saturated FA | MR Egger | 23 | −0.105 | 0.339 | 1.111 (0.572, 2.157) | 0.759 |
| Weighted median | 0.108 | 0.200 | 1.114 (0.758, 1.637) | 0.590 | ||
| IVW(random effects) | −0.236 | 0.191 | 0.790 (0.544, 1.148) | 0.216 | ||
| Maximum likelihood | −0.234 | 0.132 | 0.791 (0.611, 1.025) | 0.076 | ||
| Penalised weighted median | 0.109 | 0.192 | 1.115 (0.749, 1.659) | 0.517 | ||
| polyunsaturated FA | MR Egger | 19 | −0.589 | 0.472 | 0.555 (0.220, 1.401) | 0.230 |
| Weighted median | −0.073 | 0.240 | 0.930 (0.581, 1.488) | 0.761 | ||
| IVW(random effects) | −0.193 | 0.234 | 0.825 (0.521, 1.305) | 0.411 | ||
| Maximum likelihood | −0.194 | 0.151 | 0.823 (0.613, 1.107) | 0.199 | ||
| Penalised weighted median | −0.017 | 0.242 | 0.983 (0.611, 1.582) | 0.944 | ||
| monounsaturated FA | MR Egger | 19 | −0.091 | 0.425 | 0.913 (0.397, 2.098) | 0.832 |
| Weighted median | 0.088 | 0.232 | 1.092 (0.692, 1.723) | 0.705 | ||
| IVW(random effects) | −0.045 | 0.216 | 0.956 (0.626, 1.460) | 0.835 | ||
| Maximum likelihood | −0.046 | 0.156 | 0.955 (0.703, 1.295) | 0.765 | ||
| Penalised weighted median | 0.134 | 0.239 | 1.144 (0.717, 1.826) | 0.573 | ||
| Omega-3 FA | MR Egger | 21 | −0.863 | 0.307 | 0.422 (0.231, 0.770) | 0.0111 |
| Weighted median | −0.723 | 0.215 | 0.485 (0.318, 0.740) | 7.706 × 10−4 | ||
| IVW(fixed effects) | −0.509 | 0.136 | 0.601 (0.461, 0.784) | 1.766 × 10−4 | ||
| Maximum likelihood | −0.493 | 0.137 | 0.610 (0.466, 0.799) | 3.262 × 10−4 | ||
| Penalised weighted median | −0.787 | 0.209 | 0.455 (0.302, 0.685) | 1.628 × 10−4 | ||
| Omega-6 FA | MR Egger | 14 | −0.874 | 0.456 | 0.417 (0.171, 1.021) | 0.079 |
| Weighted median | −0.303 | 0.249 | 0.738 (0.454, 1.202) | 0.223 | ||
| IVW(random effects) | −0.285 | 0.246 | 0.752 (0.464, 1.217) | 0.246 | ||
| Maximum likelihood | −0.278 | 0.173 | 0.757 (0.539, 1.063) | 0.108 | ||
| Penalised weighted median | −0.280 | 0.263 | 0.756 (0.451, 1.265) | 0.286 |
No. SNP, number of SNPs included in the analysis. β: the regression coefficient based on fatty acids raising effect allele. SE, standard error. p < 0.05 represents the causal link of fatty acid with CD.