FIGURE 2.

FABP5 promotes PPARγ activity. (A) Schematic of the reconstitution of FABP5 expression using a lentivirus in FABP5‐deficient mice by intranasal instillation. (B) FABP5 and PPARγ colocalization in CD68‐positive cells in lung tissues of FABP5‐deficient mice reconstituted with Lenti‐FABP5 and exposed to cigarette smoke and bacterial infection. Representative picture of two independent experiments with 4–5 mice in each group. (C) PPARγ activity measured by an ELISA‐based assay in whole lung of FABP5‐deficient mice reconstituted with Lenti‐Control (green) or Lenti‐FABP5 (red) and exposed to cigarette smoke and bacterial infection. *p < .05. n = 4 mice per group. (D) KEGG pathway analysis of genes significantly enriched by at least 2‐fold among FABP5^high, compared to FABP5^low expression among healthy human and COPD lung samples. Data were analyzed from a previous RNA‐seq study (GSE57148) ²⁷