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. 2022 Jul 15;11(14):2212. doi: 10.3390/cells11142212

Figure 1.

Figure 1

Renal function and structure in diabetic ob/ob mice. Microalbuminuria (µAlb)-creatinine ratio (A), blood glucose (B) and cholesterol (C), representative examples of Periodic Acid-Schiff (PAS), Masson’s trichrome coloration (×100), and α-SMA immunofluorescence staining (×200) (D), nephrin and α-SMA protein expressions by WB (E,F), and mRNA gene expressions of VCAM-1, Acta2, and N-GAL (G), in ob/ob mice. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 compared to WT controls. Bars = 50 µM (right) and 100 µM (middle, left). n = 10 WT mice vs. 11 ob/ob mice (A–D,G). In WB experiments, n = 4 mice per group, WT, and 12 weeks or 18 weeks old ob/ob mice (E,F).