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. 2022 Jul 26;130(7):077005. doi: 10.1289/EHP10009

Figure 5.

Figures 5-1 and 5-2 are two line graphs, plotting log to the base 10 of relative liver weight underscore mean, ranging from 0.3 to 0.7 in increments of 0.1 and log to the base 10 of normalized response, ranging from 0.00 to 0.25 in increments of 0.05 (y-axis) across log to the base 10 of time weighted average, ranging from negative 2 to 3 in unit increments (x-axis). Figure 5-3 is an image lists the following: Perfluorobutanesulfonic acid, Perfluorohexane sulfonate, Perfluorooctane sulfonate, Perfluorobutanoic acid, Perfluorohexanoic acid, Perfluorooctanoic acid, Perfluorononanoic acid, Perfluorododecanoic acid, and Hexafluoropropylene oxide dimer acid.

Dose–response curves for mean relative liver weight increase (g/100 g body weight) plotted against the internal dose (expressed as TWA in milligrams per milliliter) on a log10-scale for nine PFAS, obtained by fitting the exponential model with a study-specific (modeled) background response (left plot) and normalized to the background response (right plot). Note: Figures represent geometric mean response for each dose group, as derived from the summary data (Table S1). For clarity, the whiskers indicating the 95% confidence intervals of the means are not plotted in the right plot. HFPO-DA, hexafluoropropylene oxide-dimer acid; PFAS, per- and polyfluoroalkyl substances; PFBA, perfluorobutanoic acid; PFBS, perfluorobutane sulfonic acid; PFDoDA, perfluorododecanoic acid; PFHxA, perfluorohexanoic acid; PFHxS, perfluorohexane sulfonic acid; PFNA, perfluorononanoic acid; PFOA, perfluorooctanoic acid; PFOS, perfluorooctane sulfonic acid; rLW, relative liver weight; TWA, time-weighted average.