. 2022 Jul 26;130(7):077005. doi: 10.1289/EHP10009

Table 1.

Toxicokinetic model parameter values of per- and polyfluoroalkyl substances (PFAS).

Compound	Study	Evaluation of TK model fit	Dose (mg/kg)	$F_{a b s}$ (−)	$T_{m a x}$ (h)	V1 (mL/kg)	$α$ T1/2 (h)	$β$ T1/2 (h)	k10 T1/2 (h)	k01 (1/h)	k10 (1/h)	k12 (1/h)ⁱ	k21 (1/h)ⁱ
PFBA	Chang et al.⁶⁸	Monophasic^a	30	1.0^b	1.25^a	209^a	—	—	9.22^a	3.0^a	0.075^h	—	—
PFHxA	Dzierlenga et al.⁸¹	Biphasic^a	160	1.0^b	0.890^a	348^a	1.46^a	13.7^a	1.63^a	2.2^f	0.43^h	0.039	0.056
PFOA	Dzierlenga et al.⁸¹	Monophasic^a	12	1.0^b	6.37^a	154^a	—	—	258^a	0.92^f	0.0027^h	—	—
PFNA	Tatum-Gibbs et al.¹⁰¹	Monophasic^c	3	1.0^b	—	170^j	—	—	—	1.0^b	0.00025^j	—	—
PFDA	Dzierlenga et al.⁸¹	Biphasic^a	10	1.0^b	9.06^a	228^a	123^a	995^a	478^a	0.50^f	0.0015ⁱ	0.0021	0.0027
PFDoDA	Kawabata et al.⁷³	Monophasic^a	50	1.0^a	120^a^,^g	663^d	—	—	1,327^a^,^g	0.036^f	0.00052^h	—	—
PFBS	Huang et al.¹⁰²	Biphasic^a	20	1.0^b	2.18^a	148^a	2.37^a	5.36^a	2.73^a	0.68^f	0.25^h	0.018	0.15
PFHxS	Huang et al.¹⁰²	Monophasic^a	16	1.0^b	5.89^a	137^a	—	—	396^a^,^g	1.1^f	0.0018^h	—	—
PFOS	Huang et al.¹⁰²	Biphasic^a	2	1.0^b	14.3^a	280^a	74.4^a^,^g	972^a^,^g	478^a^,^g	0.24^f	0.0015^h	0.0040	0.0045
HFPO-DA	Gannon et al.⁸⁰^,^e	Biphasic^a	10	1.0^a	—	142^a	2.8^a	72.2^a	—	3.3^a	0.24^k	0.0099	0.010

Note: —, no data; $α$ T1/2, alpha elimination half-life; $β$ T1/2, beta elimination half-life; HFPO-DA, hexafluoropropylene oxide-dimer acid; $F_{a b s}$ , fraction of the amount of a PFAS in the gastrointestinal tract that will be absorbed over time; k01, absorption rate constant from the gastrointestinal tract into Compartment 1; k10, elimination rate constant from Compartment 1; k10 T1/2, elimination half-life from Compartment 1; k12, transfer constant from Compartment 1 to Compartment 2; k21, transfer constant from Compartment 2 to Compartment 1; PFAS, per- and polyfluoroalkyl substances; PFBA, perfluorobutanoic acid; PFBS, perfluorobutane sulfonic acid; PFDoDA, perfluorododecanoic acid; PFHxA, perfluorohexanoic acid; PFHxS, perfluorohexane sulfonic acid; PFNA, perfluorononanoic acid; PFOA, perfluorooctanoic acid; PFOS, perfluorooctane sulfonic acid; TK, toxicokinetic; $T_{m a x}$ , time at maximum serum concentration; V1, volume of distribution of Compartment 1.

^{^a}

Value provided in the study from oral, single exposure of males at the dose provided in column “dose.”

^{^b}

Based on assumption in the original studies.

^{^c}

In the original publication the authors report that the data illustrated biphasic kinetics. See Supplementary Material, “Toxicokinetic model parameterization.”

^{^d}

Calculated in this study. See Supplemental Material, “Toxicokinetic model parameterization.”

^{^e}

Serum concentrations per individual animal over time reported in Gannon.¹⁰⁵ Note that 12-h concentrations were assumed to be transposed in the original report. See also Supplementary Material, “Toxicokinetic model parameterization.”

^{^f}

Calculated according to Equation 5.

^{^g}

Provided in study in different unit (days).

^{^h}

Calculated according Equation 4.

^ⁱ

Calculated according to method in Supplemental Material, “Toxicokinetic model parameterization.”

^{^j}

Optimized; note that study reports other values for V1 and k10. See remarks in Supplemental Material, “Toxicokinetic model parameterization.”

^{^k}

Optimized according to the method shown in Supplemental Material, “Toxicokinetic model parameterization.”