Table 2.

Comparison of reported and modeled area under the curve (AUC), maximum serum concentration ($C_{max}$), and time at maximum serum concentration ($T_{max}$) for the single-dose experiments.

Compound	Study	AUC				$C_{max}$				$T_{max}$ (h)
		Reported	Modeled	Ratio	Unitb	Reported	Modeled	Ratio	Unitb	Reported	Modeled	Ratio
PFBA	Chang et al.68	1,900	1,600	1.2	$\mathrm{\mu }\mathrm{g}\times \mathrm{h}/\mathrm{mL}$	130	130	1.0	µg/mL	1.3	1.3	1.0
PFHxA	Dzierlenga et al.81	3.5	3.4	1.0	$\text{mM}\times \mathrm{h}$	0.97	0.96	1.0	mM	0.89	0.91	1.0
PFOA	Dzierlenga et al.81	70	67	1.0	$\text{mM}\times \mathrm{h}$	0.19	0.18	1.1	mM	6.4	6.4	1.0
PFNA	Tatum-Gibbs et al.101	15,000	18,000	0.8	$\mathrm{mg}\times \mathrm{h}/\mathrm{L}$	22	18	1.2	µg/mL	—	8.8	—
PFDA	Dzierlenga et al.81	59	54	1.1	$\text{mM}\times \mathrm{h}$	0.083	0.082	1.0	mM	9.1	11	0.8
PFDoDA	Kawabata et al.73	—	140	—	$\text{mM}\times \mathrm{h}$	54	70	0.8	µg/mL	120	120	1.0
PFBS	Huang et al.102	1.8a	1.8	1.0	$\text{mM}\times \mathrm{h}$	0.25	0.24	1.0	mM	2.2	2.3	1.0
PFHxS	Huang et al.102	170a	150	1.1	$\text{mM}\times \mathrm{h}$	0.29	0.29	1.0	mM	5.9	5.9	1.0
PFOS	Huang et al.102	9.9a	8.9	1.1	$\text{mM}\times \mathrm{h}$	0.010	0.013	0.8	mM	14	17	0.8
HFPO-DA	Gannon et al.80	—	0.88	—	$\text{mM}\times \mathrm{h}$	—	0.17	—	mM	—	0.86	—

Note: —, no data; HFPO-DA, hexafluoropropylene oxide-dimer acid; PFBA, perfluorobutanoic acid; PFBS, perfluorobutane sulfonic acid; PFDoDA, perfluorododecanoic acid; PFHxA, perfluorohexanoic acid; PFHxS, perfluorohexane sulfonic acid; PFNA, perfluorononanoic acid; PFOA, perfluorooctanoic acid; PFOS, perfluorooctane sulfonic acid.

^a AUC units in Huang et al.¹⁰² should be $\text{mM}\times \mathrm{h}$ (C.R. Blystone, personal communication).

^b Units reported in the study are used.