Table 3.

External dose and modeled and reported concentrations at the end of the study for each of the doses in 28-d repeated-dose toxicity studies for male rats specifically.

Compound	Reference	External dose (mg/kg body weight/d)	Concentration at end of the study (mg/mL)
			Modeled	Reported mean	Ratio
PFBS	NTP99	62.6	3.7	2.2	1.3
		125	7.4	5.3	1.4
		250	15	12	1.3
		500	30	43	0.7
PFHxS	NTP99	0.625	71	66	1.1
		1.25	140	92	1.5
		2.5	280	130	2.2
		5	570	160	3.6
		10	1,100	200	5.5
PFOS	NTP99	0.312	13	24	0.5
		0.625	26	52	0.5
		1.25	52	94	0.6
		2.5	100	170	0.6
		5	210	320	0.7
PFHxA	NTP100	62.6	1	0.38	2.6
		125	2	0.50	4.0
		250	4	1.3	3.1
		500	8.1	3.4	2.4
		1,000	16	11	1.5
PFOA	NTP100	0.625	48	51	0.9
		1.25	96	73	1.3
		2.5	190	95	2.0
		5	380	110	3.5
		10	770	150	5.1
PFNA	NTP100	0.625	95	57	1.7
		1.25	190	160	1.2
		2.5	380	380	1.0
		5	760	360	2.1
PFDA	NTP100	0.156	9	8.5	1.1
		0.312	18	23	0.8
		0.625	36	43	0.8
		1.25	72	100	0.7
		2.5	140	260	0.5

Note: NTP, National Toxicology Program; PFBS, perfluorobutane sulfonic acid; PFDA, perfluorodecanoic acid; PFHxA, perfluorohexanoic acid; PFHxS, perfluorohexane sulfonic acid; PFNA, perfluorononanoic acid; PFOA, perfluorooctanoic acid; PFOS, perfluorooctane sulfonic acid.