Table 4.

External dose, modeled TWA (time-weighted average) serum concentration, and modeled and reported concentrations at the end of the study for each of the doses in subchronic repeated-dose toxicity studies for male rats specifically.

Substance	Reference	External dose (mg/kg body weight/d)	Modeled TWA (mg/mL)	Concentration at end of the study (mg/mL)
				Modeled	Reported mean	Ratio
PFBS	Lieder et al.86	30	0.016	0.0018	—	—
		100	0.053	0.0059	—	—
		300	0.16	0.018	—	—
		1,000	3.7	0.059	—	—
PFHxS	Butenhoff et al.87	0.3	0.024	0.042	0.044	1.0
		1	0.080	0.14	0.089	1.6
		3	0.24	0.42	0.13	3.2
		10	0.80	1.4	0.20	7.0
PFOS	Seacat et al.88	0.03	0.0015	0.0025	0.0040	0.6
		0.13	0.0065	0.011	0.017	0.6
		0.34	0.017	0.029	0.044	0.7
		1.33	0.066	0.11	0.15	0.7
PFBA	Butenhoff et al.89	1.2	0.0028	0.0012	0.0061	0.2
		6	0.014	0.0061	0.014	0.4
		30	0.071	0.030	0.052	0.6
PFHxA	Loveless et al.90	20	0.0017	0.00032	—	—
		100	0.0083	0.0016	—	—
		500	0.041	0.0081	—	—
PFOA	Perkins et al.91	0.06	0.0047	0.0059	0.0071	0.8
		0.64	0.050	0.062	0.041	1.5
		1.94	0.15	0.19	0.070	2.7
		6.5	0.51	0.63	0.14	4.5
PFNA	Mertens et al.92	0.025	0.0044	0.010	—	—
		0.125	0.022	0.051	—	—
		0.6	0.11	0.25	—	—
PFDoDA	Kato et al.93	0.1	0.0019	0.0049	—	—
		0.5	0.0096	0.024	—	—
		2.5	0.048	0.12	—	—
HFPO-DA	Haas94	0.1	0.000051	0.000069	—	—
		10	0.0051	0.00069	—	—
		100	0.051	0.0069	—	—

Note: —, no data; HFPO-DA, hexafluoropropylene oxide-dimer acid; PFBA, perfluorobutanoic acid; PFBS, perfluorobutane sulfonic acid; PFDoDA, perfluorododecanoic acid; PFHxA, perfluorohexanoic acid; PFHxS, perfluorohexane sulfonic acid; PFNA, perfluorononanoic acid; PFOA, perfluorooctanoic acid; PFOS, perfluorooctane sulfonic acid.