FIGURE 3.
Collagen turnover products correlate with survival in pulmonary fibrosis. Neoepitope biomarkers of types III and VI collagen turnover (C3M, C6M, PRO‐C3 and PRO‐C6) were measured in 185 patients with newly diagnosed idiopathic pulmonary fibrosis. High baseline levels of C3M, C6M, PRO‐C3 and PRO‐C6 were associated with more advanced disease at the time of diagnosis. Figures show Kaplan–Meier curves of survival of participants in the Pulmonary Fibrosis Biomarker (PFBIO) cohort followed up for 3 years. Patients are divided according to the number of high neoepitope biomarkers (C3M, C6M, PRO‐C3 and PRO‐C6) at baseline. Reproduced from Hoyer et al., 52 with permission