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. 2022 Jun 30;14(7):1387. doi: 10.3390/pharmaceutics14071387

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Antigen presentation of bone-marrow-derived CD103⁺ DCs after transfection with LAH4-L1 (L1)- or LAH4-L1R (L1R)-formulated tOVA mRNA. CD103⁺ DCs were generated and transfected on day 13 with mRNA encoding tOVA (unmodified, RNA/modified, MOD). The next day, cells were harvested and stained for DC markers and SIINFEKL presented in MHC I (MHCI-S). Percentage (a) and MFI (b) for SIINFEKL presented in MHC I within the CD11c⁺ CD103⁺ population; cells were pulsed with SIINFEKL peptide (SII) as a positive control; positive control for transfection was performed with jetMessenger^® (JM). Mock controls were performed without mRNA. n = 6; each dot represents one replicate, mean ± SD. One-way ANOVA, Tukey’s multiple comparison test: ** p < 0.01, *** p < 0.001, ns—not significant.