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. 2022 Jun 30;15(7):814. doi: 10.3390/ph15070814

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effect of brussonol on the cytosolic Ca²⁺ mobilization in P. falciparum loaded with Fluo-4 AM calcium indicator. (a) Chemical structure of brussonol and CPA. The fused rings are highlighted for comparison purposes. Representative traces of [Ca²⁺]_cyt rise induced by 10 μM brussonol (b) and 10 μM CPA (c) in MOPS buffer containing Ca²⁺. (d) Histograms of the increase in the cytosolic Ca²⁺ levels with the addition of CPA (10 μM), brussonol (10 μM), and brussonol (10 μM) after and before treatment with CPA (10 μM). The data analyzed were collected from two independent experiments.

Effect of brussonol on the cytosolic Ca²⁺ mobilization in P. falciparum loaded with Fluo-4 AM calcium indicator. (a) Chemical structure of brussonol and CPA. The fused rings are highlighted for comparison purposes. Representative traces of [Ca²⁺]_cyt rise induced by 10 μM brussonol (b) and 10 μM CPA (c) in MOPS buffer containing Ca²⁺. (d) Histograms of the increase in the cytosolic Ca²⁺ levels with the addition of CPA (10 μM), brussonol (10 μM), and brussonol (10 μM) after and before treatment with CPA (10 μM). The data analyzed were collected from two independent experiments.