Table 2.
IC50 values of compound brussonol against a panel of sensitive and resistant P. falciparum strains.
| Pf Strain | IC50brussonol (µM) | RI | IC50PYR (µM) |
RI | IC50ATV (µM) |
RI | IC50ART (µM) |
RI | IC50MMV848 (µM) |
RI |
|---|---|---|---|---|---|---|---|---|---|---|
| 3D7 | 13 ± 2 | 1 | 0.06 ± 0.01 | 1 | 0.0007 ± 0.0003 | 1 | 0.008 ± 0.004 | 1 | 0.13 ± 0.02 | 1 |
| K1 | 6.6 ± 0.1 | 0.5 | >10 | >166 | NT | NT | 0.007 ± 0.003 | 1 | NT | NT |
| Dd2 | 7 ± 2 | 0.5 | >10 | >166 | NT | NT | 0.011 ± 0.008 | 1 | NT | NT |
| TM90C6B | 7 ± 2 | 0.5 | NT | NT | 3 ± 1 | 4285 | 0.006 ± 0.002 | 1 | NT | NT |
| 3D7r_MMV848 | 12 ± 3 | 1 | NT | NT | NT | NT | 0.013 ± 0.008 | 2 | 2.4 ± 0.4 | 18 |
Data represent mean ± standard deviation of at least two independent experiments conducted in triplicate; RI = IC50resistant strain/IC503D7; NT = not tested; PYR = pyrimethamine; ATV = atovaquone; ART = artesunate; MMV848 = PfPI4K inhibitor.