Table 2.
Independent Variables | Levels | Response | Constrains | ||
---|---|---|---|---|---|
−1 | 0 | +1 | |||
TPP concentration (mg/mL) |
0.1 | 0.35 | 0.6 | Particle size | Minimize |
PDI | <0.5 | ||||
CS concentration (mg/mL) | 0.3 | 0.65 | 1 | Zeta potential | 30–40 mV |
Encapsulation efficiency | Maximize | ||||
Ultra-sonication energy (watt) | 10 | 25 | 40 | Release type | Sustained Release |