TABLE 3.
Comparison of patients treated with mild therapeutic hypothermia versus normothermia
| MTH (n = 81) | NT (n = 0) | p‐value | |
|---|---|---|---|
| Age in years, median (IQR) | 62 (51–70) | 69 (56–78) | .004 |
| Female, n (%) | 21 (26) | 30 (33) | .292 |
| Bystander‐initiated CPR, n (%) | 63 (78) | 57 (63) | .040 |
| Time to ROSC >20 min, n (%) | 44 (54) | 47 (52) | .844 |
| Cardiac arrest out of hospital, n (%) | 77 (95) | 69 (77) | .001 |
| Shockable first monitored rhythm, n (%) | 70 (86) | 34 (38) | .0001 |
| SOFA score on admission, median (IQR) | 10 (8–11) | 10 (9–12) | .214 |
| APACHE II on admission, median (IQR) | 25 (21–29) | 27 (23–31) | .001 |
| Lactate at admission [mg/dl], median (IQR) | 42 (30–75) | 52 (24–102) | .459 |
| CRP max [mg/dl], median (IQR) | 16.1 (11.3–22.4) | 11.2 (7.0–20.7) | .012 |
| PCT max [µg/L], median (IQR) | 1.7 (0.5–8.3) | 5.0 (0.9–19.5) | .063 |
| Leucocyte count max [G/L], median (IQR) | 17.7 (13.9–23.6) | 16.4 (12.9–22.0) | .251 |
| VAP, n (%) | 24 (30) | 15 (7) | .040 |
| McVAP, n (%) | 8 (10) | 2 (7) | .034 |
| Ventilator‐dependent days, median (IQR) | 6 (3–8) | 3 (1–6) | .001 |
| Poor outcome at hospital discharge, n (%) | 36 (44) | 56 (62) | .020 |
| Mortality, n (%) | 31 (38) | 52 (57) | .011 |
Abbreviations: MTH, mild therapeutic hypothermia; NT, normothermia; VAP, ventilator‐associated pneumonia; CPR, cardiopulmonary resuscitation; ROSC, return of spontaneous circulation; SOFA, sequential organ failure assessment; APACHE II, acute physiology and chronic health evaluation II; CRP max, C‐reactive protein (maximum within 192 h); PCT max, procalcitonin (maximum within 192 h); Leukocyte count max, leukocyte count (maximum within 192 h).