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. 2022 Jul 19;14(7):1566. doi: 10.3390/v14071566

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Number of nucleotide substitutions necessary to acquire a tribasic cleavage site in HAs from LPAIVs. The number of single nucleotide substitutions required to obtain a tribasic cleavage site, defined as containing at least three basic amino acids in P1 to P4 and an arginine in P1, excluding histidine and pyrimidine-containing arginine codons based on codon usage in HPAIVs, in all reported LPAIV sequences from H1–H16 HA subtypes. The exact percent of sequences is indicated on top of each bar and a darker blue color indicates fewer substitutions required (Adapted from [183], reproduced with permission from Mathis Funk, Viruses; published by MDPI, 2022).