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. 2022 Jul 26;17(7):e0271188. doi: 10.1371/journal.pone.0271188

Table 1. Antimicrobial utilization (DID) by chemical class and molecule in the year pre- and post-policy enforcement in Saudi Arabia.

A] DID by chemical class
Pre-policy period (May 2017 to April 2018) Post-policy period (June 2018 to May 2019)
Penicillin (J01C) 3.78 2.88
Trichomonacides (G01A) 1.66 1.54
Fluoroquinolones (J01MA) 0.65 0.56
Macrolides and lincosamides (J01F) 0.43 0.36
Cephalosporins, carbapenem and monobactam (J01D) 0.35 0.29
Tetracyclines (J01A) 0.28 0.25
Anti-infective agents (urinary) (G04A) 0.16 0.08
Anaerobicides (J08B) 0.11 0.08
Systemic antifungal agents (J02A) 0.08 0.09
Trimethoprim combinations (J01E) 0.07 0.05
Antiviral agents (J05B) 0.01 0.08
Amebicides (P01A) 0.01 0.01
Total 7.59 6.27
B] DID by molecule
Amoxicillin, Clavulanic Acid 4.54 3.93
Amoxicillin 3.02 1.81
Metronidazole 1.77 1.61
Cefuroxime Axetil 1.70 1.40
Azithromycin 1.45 0.98
Ciprofloxacin 1.22 1.00
Clarithromycin 0.94 0.92
Doxycycline 0.80 0.67
Levofloxacin 0.44 0.39
Moxifloxacin 0.24 0.24
Fluconazole 0.08 0.09
Cefalexin 0.08 0.03
Sulfamethoxazole trimethoprim 0.07 0.04

DID, defined daily dose per 1000 inhabitants per day