Table 2. Meta-analysis of PD-L1 expression and clinicopathological features in SGC patients.
| Clinical parameters | No. of studies (No. of patients) | OR (95%CI) | Model | Heterogeneity | Significance(P) | |
|---|---|---|---|---|---|---|
| I 2 | P | |||||
| Gender (Male&Female) | 7(614) [16, 17, 42–46] | 1.735(1.194–2.521) | Fixed | 27.50% | 0.219 | 0.004 |
| Age (Old&Young)a | 7(614) [16, 17, 42–46] | 1.536(1.063–2.218) | Fixed | 28.20% | 0.213 | 0.022 |
| T stage (T3T4&T1T2) | 8(811) [16, 19, 41–46] | 1.829(1.019–3.283) | Random | 56.60% | 0.024 | 0.043 |
| N stage (N+&N-) | 7(694) [16, 41–46] | 3.263(2.276–4.679) | Fixed | 0.00% | 0.462 | 0.000 |
| Clinical Stage (III+IV&I+II) | 2(120) [17, 44] | 2.115(0.720–6.212) | Random | 48.90% | 0.162 | 0.173 |
| Pathological Grade (H&L+M) | 4(449) [16, 41, 44, 45] | 7.248(4.335–12.118) | Fixed | 20.70% | 0.286 | 0.000 |
| PNI (P&N) | 4(453) [16, 43, 44, 46] | 1.460(0.596–3.577) | Random | 70.70% | 0.017 | 0.408 |
| VI (P&N) | 4(453) [16, 43, 44, 46] | 2.812(0.940–8.407) | Random | 78.80% | 0.003 | 0.064 |
| Surgical margin (P&N) | 4(272) [19, 43–45] | 1.043(0.577–1.885) | Fixed | 10.10% | 0.343 | 0.889 |
| Subtype (non-ACC&ACC) | 5(554) [16, 41, 42, 45, 47] | 7.714(1.509–39.442) | Random | 71.30% | 0.008 | 0.014 |
| Treatment Failure (P&N) | 3(194) [17, 19, 45] | 1.417(0.360–5.571) | Random | 72% | 0.028 | 0.618 |
a: Cutoff value of age included 45,60,61,63,64,65 and 66 years old, according to the median age of the included studies; OR, odds ratio; T stage, tumor stage; N stage, node stage; H, high; L, low; M, medium; PNI, perineural invasion; VI, vascular invasion; N, negative; P, positive; ACC, adenoid cystic carcinoma