Table 3. Development of geographic location of clinical trial sites from 2008–2019 spread over 9 geographic regions including North America, Latin America, Northern Europe, Western Europe, Southern Europe, Asia/Pacific, Africa and Oceania.
Each clinical trial may have registered several geographical regions.
| Geographic region | Trials completed 2008–2011 | Trials completed 2012–2015 | Trials completed 2016–2019 | p-value |
|---|---|---|---|---|
| North America (%) | 271 (73) | 253 (65) | 232 (65) | 0.03287 |
| Latin America (%) | 59 (16) | 43 (11) | 57 (16) | 0.07967 |
| Northern Europe (%) | 69 (18.5) | 73 (19) | 96 (27) | 0.006061 |
| Western Europe (%) | 87 (24) | 105 (27) | 125 (35) | 0.001416 |
| Southern Europe (%) | 73 (20) | 86 (22) | 122 (34) | 6.03e-06 |
| Eastern Europe (%) | 68 (18) | 105 (27) | 134 (38) | 3.02e-08 |
| Asia/Pacific (%) | 87 (23) | 128 (33) | 184 (52) | 4.21e-15 |
| Africa (%) | 29 (8) | 34 (9) | 45 (13) | 0.06161 |
| Oceania (%) | 30 (8) | 27 (7) | 52 (15) | 0.0007428 |