TABLE 1.
Patients with cirrhosis (n = 16) | Patients without cirrhosis (n = 7) | ||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
P2 | P4 | P6 | P7 | P9 | P10 | P11 | P12 | P13 | P14 | P17 | P18 | P19 | P20 | P21 | P23 | P1 | P3 | P5 | P8 | P15 | P16 | P22 | |
Sex/Age | M/68 | F/46 | F/67 | M/52 | M/51 | F/37 | M/42 | F/45 | M/66 | F68 | F36 | M/59 | M/37 | F/50 | F/64 | M/53 | F/66 | F/42 | M/42 | F/29 | F36 | F39 | M/30 |
Previous IFN | Yes | Yes | Yes | Yes | Yes | Yes | No | No | Yes | Yes | No | Yes | Yes | Yes | No | Yes | Yes | Yes | Yes | Yes | Yes | Yes | No |
HDV‐RNA copies/mL | 2.8e6 | 2.1e6 | 1.6e5 | 7.1e2 | 3.7e3 | 2.7e5 | 3.1e4 | 1.2e4 | 5.8e3 | 8.2e5 | 1.0e2 | 1.0e6 | 1.6e6 | 4.3e5 | 2.1e7 | 2.1e7 | 5.9e6 | 5.2e5 | 9.5e4 | 4.3e5 | 1.1e6 | 2.3e3 | 2.1e7 |
HBeAg | neg | neg | neg | neg | neg | neg | neg | neg | neg | neg | neg | neg | neg | neg | neg | neg | neg | pos | neg | pos | neg | neg | neg |
HBV‐DNA (IU/mL) | <20 | neg | <20 | neg | neg | 63 | <20 | neg | neg | neg | neg | neg | neg | 347 | neg | 0 | 21 | <20 | neg | <20 | neg | <20 | 6000 |
HBsAg, quant | 3142 | 9377 | 420 | 1229 | 1663 | — | 13,649 | 181 | 45 | 2090 | 2266 | 4673 | 2183 | 1161 | — | — | 9780 | 11,825 | 1090 | 17,326 | 5890 | 3643 | — |
VCTE‐LSM (kPa) | 26.3 | 17.2 | 10.2 | — | 35.8 | 14.6 | 22.7 | 18.6 | 7.5 | — | 24 | — | 48 | 19.4 | — | 31.6 | — | 9.1 | 7.4 | 5.5 | 7 | 9.5 | 6.8 |
Bilirubin (mg/dl) | 1.38 | 0.52 | 0.35 | 0.49 | 0.95 | 1.2 | 1.37 | 1.12 | 1.35 | 1.54 | 0.65 | 1.24 | 0.8 | 1.6 | 0.3 | 1.6 | 0.36 | 0.47 | 0.52 | 0.5 | 0.28 | 0.65 | 0.64 |
Albumin (g/dl) | 34.4 | 31.0 | 44.8 | 44.1 | 46.1 | 43.0 | 38.1 | 41.8 | 39.9 | 33.9 | 49.9 | 41.9 | 36.7 | 32.5 | 41.0 | 34.9 | 41.3 | 45.6 | 44.0 | 35.6 | 43.0 | 45.6 | 47.6 |
INR | 1.3 | 1.4 | 1.0 | 1.0 | 1.2 | 1.2 | 1.2 | 1.0 | 1.4 | 1.7 | 1.2 | 1.2 | 2.4 | 1.3 | 1.0 | 1.4 | 1.0 | 1.0 | 1.0 | 1.2 | 1.1 | 1.3 | 1.0 |
Platelets (G/L) | 77 | 98 | 131 | 166 | 84 | 129 | 109 | 29 | 90 | 63 | 85 | 86 | 78 | 53 | 126 | 140 | 216 | 251 | 162 | 288 | 257 | 206 | 166 |
AST (IU/L) | 55 | 93 | 64 | 21 | 68 | 48 | 87 | 35 | 36 | 94 | 24 | 101 | 56 | 315 | 50 | 120 | 111 | 76 | 68 | 53 | 51 | 203 | 43 |
ALT (IU/L) | 63 | 80 | 75 | 25 | 125 | 56 | 115 | 35 | 44 | 69 | 24 | 132 | 73 | 307 | 42 | 100 | 224 | 91 | 207 | 42 | 59 | 341 | 98 |
GGT (IU/L) | 30 | 52 | 43 | 37 | 98 | 31 | 177 | 16 | 26 | 48 | 30 | 88 | 141 | 82 | 45 | 91 | 44 | 64 | 86 | 16 | 32 | 58 | 49 |
Concomitant NAtherapy | ETV | ETV | TDF | TDF | ETV | TAF | TDF | No | TDF | TAF | TDF | TDF | TDF | TDF | TDF | TDF | TDF | TDF | TDF | No | TDF | TDF | TDF |
Abbreviations: ETV, entecavir; NUC, nucleos(t)ide analog; TAF, tenofovir alafenamide; TDF, tenofovir disoprixile fumarate; VCTE‐LSM, liver stiffness measurement by vibration controlled transient elastography.