Table 3.
miRNAs regulating DDP-therapy response, confirmed in three different types of experiments (data based on DDP-resistance studies and extracted from Tables S1 and S2).
| DDP R/DDP S miRNA | Downstream Regulation | Reference |
|---|---|---|
| miR-21 | PTEN | [55,56,57,58] |
| miR-27a | RKIP | [59,60] |
| miR-92b-3p | PTEN | [23,61] |
| miR-130b | PTEN | [62] |
| miR-146a | CHOP | [54] |
| miR-224 | p-21 | [62] |
| miR-324-5p | FBXO11 | [63] |
| miR-425-3p | AKT1 | [26] |
| miR-1269b | PTEN | [64] |
| let7 a,b,c,d,e,f,g,i | LIN28 | [36,48] |
| miR-29c | AKT2 | [65] |
| miR-30b-5p | LRP8 | [66] |
| miR-34c-3p | Notch | [35] |
| miR-100-5p | mTOR | [25] |
| miR-101 | ABCC1, ROCK2 | [67,68] |
| miR-145-5p | ABCC1 | [69] |
| miR-146a | JNK2, CEACAM6, CCNJ | [70,71,72] |
| miR-181b | BCL2, TGFβR1, Notch2 | [73,74,75,76] |
| miR-193 | LRRC1 | [77] |
| miR-378 | sCLU | [78] |
| miR-379 | EIF4G2 | [79] |
| miR-381 | NFkB | [80] |
| miR-451a | MCL-1 | [81,82,83] |
| miR-486-5p | TWF1 | [84] |
| miR-613 | GJA1 | [85,86] |
DDP—cisplatin; DDP-S miRNA—miRNA associated with DDP sensitivity; DDP-R miRNA—miRNA associated with DDP resistance.