Table 4.
The involvement of selected miRNAs in crucial steps of tumorigenesis.
| DDPR/DDP S miRNA | Apop-tosis | EMT | Cell Cycle Progression | Auto-Phagy | Proliferation | Cell Growth | Angio-Genesis | Meta-Stasis | Invasion | Reference |
|---|---|---|---|---|---|---|---|---|---|---|
| miR-21 | ↓ | ↑ | ↑ | ↑ | ↑ | ↑ | [87,88] | |||
| miR-27a | ↑ | [60] | ||||||||
| miR-130b | ↑ | ↑ | ↑ | ↑ | ↑ | [88,89,90] | ||||
| Let7-a | ↓ | ↓ | ↓ | [91,92,93] | ||||||
| Let7-f | ||||||||||
| Let7-g | ↑ | ↓ | ↓ | [94,95] | ||||||
| Let7-i | ↓ | [96] | ||||||||
| miR-29c | ↓ | [65] | ||||||||
| miR-181b | ↑ | ↓ | ↓ | ↓ | [73,76,97,98,99] | |||||
| miR-193 | ↓ | ↓ | ↓ | [100] | ||||||
| miR-200b | ↑ | ↓ | ↓ | ↓ | ↓ | ↓ | [101,102,103,104] | |||
| miR-378 | ↓ | ↓ | ↓ | ↓ | ↓ | [105,106,107] |
DDP—cisplatin; DDP-S miRNA—miRNA associated with DDP sensitivity; DDP-R miRNA—miRNA associated with DDP resistance; ↑ the increased expression of selected miRNA is associated with upregulation of process; ↓ the increased expression of selected miRNA is associated with downregulation of process.