Table 1.
Morphological and immunohistochemical features of microglandular hyperplasia (MGH) and endometrioid carcinoma (EMCA)
| Gland architecture | Luminal secretions/mucin | Subnuclear vacuoles | Foamy histiocytes | Inflammation | Squamous metaplasia | Cytological atypia | Mitotic figures per 10 HPF, mean (range) | p63 positivity | Loss of PTEN expression | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Small tightly packed | Medium to large tightly packed | ||||||||||
| MGH (n = 26) | 25 (96%) | 1 (4%) | 15 (58%) | 10 (38%) | 1 (4%) | 26 (100%) | 5 (19%) | 0 (0%) | 0.1 (0–2) | 26 (100%) | 1 (4%)* |
| EMCA (n = 25) | 9 (36%) | 16 (64%) | 18 (72%) | 1** (4%) | 6 (24%) | 22 (88%) | 5 (20%) | 23 (92%) | 23 (1–25) | 4 (16%)*** | 20 (91%) **** |
Bold type indicates statistically significant differences (P‐values as follows: gland architecture 0.000, subnuclear vacuoles 0.003, foamy histiocytes 0.037, cytological atypia 0.000, p63 positivity 0.000, loss of phosphatase and tensin homologue (PTEN) expression 0.000) HPF, high‐power field.
*
24 MGH cases stained;
**
one case showed focal subnuclear vacuoles;
***
one case showed staining in squamous differentiation, three cases showed focal non‐specific staining;
****
22 EMCA cases stained.