Table 2.

Clinical, morphological and immunohistochemical features of atypical microglandular proliferations

Patient history					Morphological description								Immunohistochemical stain		Follow‐up diagnosis
Case	Age	Hormone therapy use	Postmenopausal?	Site/procedure	Gland architecture	Luminal secretions/mucin	Subnuclear vacuoles	Foamy histiocytes	Inflammation	Luminal squamous metaplasia	Cytological atypia	Mitotic figures per 10 HPG	p63	PTEN
1	93	NA	Yes	Endometrium/curettage	Small, tightly packed	Present	Absent	Present	Moderate	Present	Absent	0	Positive/subcolumnar	Intact	NA
2	76	NA	Yes	Endometrium/biopsy	Small, tightly packed	Present	Absent	Present	Absent	Absent	Absent	1	Positive/subcolumnar	Intact	NA
3	72	None	Yes	Endometrium/biopsyHysterectomy (follow‐up)	Medium and tubular, tightly packed, occasionally fused	Present	Absent	Present	Moderate	Absent	Present	3	Negative	Lost	EMCA FIGO Grade 1
4	58	None	Yes	Endometrium/biopsy	Small, tightly packed	Present	Absent	Absent	Moderate	Absent	Absent	0	Positive/focal subcolumnar	Intact	NA
5	70	None	Yes	Endometrium/biopsy and curettageHysterectomy (follow‐up)	Variable in size, tubular, tightly packed	Present	Absent	Present	Moderate	Absent	Present	6	Negative	Lost (focally intact)	EMCA FIGO Grade 1
6	45	None	No	Endometrium, Cervix/ biopsy and curettage	Small, tightly packed	Present	Absent	Present	Moderate	Present	Absent	0	Positive/subcolumnar	Intact	MGH
7	47	OCP	No	Endometrium/biopsy	Small to medium, tightly packed	Absent	Absent	Absent	Absent	Absent	Present	0	Negative	NA	NA
8	66	None	Yes	Endometrium/biopsy	Small, tightly packed	Present	Absent	Absent	Severe	Absent	Present	2	Positive (focal)	Intact	NA
9	66	None	Yes	Endometrium/curettage	Small to medium, tightly packed	Present	Absent	Absent	Moderate	Absent	Present	2	Negative	Lost	NA

EMCA, endometrial endometrioid carcinoma; MGH, microglandular hyperplasia; PTEN, phosphatase and tensin homologue; NA, not available; OCP, oral contraceptive pill.