Figure 2.
DUB categories: DUBs currently encoded in the human genome are clustered in five classes depicted in different color schemes. Of the six subfamilies, five are cysteine proteases: ubiquitin C-terminal hydrolases (UCH), ubiquitin-specific proteases (USP), zinc finger-containing ubiquitin peptidase (ZUP1), Machado-Joseph disease proteases (MJD, Josephins), and ovarian tumor proteases (OTU), and a one family belongs to the Jab1/Pab1/MPN domain-associated zinc metalloproteases (JAMM). (Created with BioRender.com, (Created with BioRender.com, accessed 20 June 2022).