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. 2022 Jul 11;14(7):1447. doi: 10.3390/pharmaceutics14071447

Figure 4.

Figure 4

Representation of THP-1 and HPAEpiC cells’ internalization kinetics of PLGA NCs: Circa 90% of macrophages have phagocytized both Cy5/PLGA- and Cy5/PLGA+ after 4 h of treatment; however, the Cy5/PLGA- system shows a faster uptake at the beginning of the treatment (A). All (100%) of epithelial cells uptake both Cy5/PLGA- and Cy5/PLGA+ NCs after 72 h of treatment; however, the Cy5/PLGA– system shows a faster uptake at 8 h of treatment (B). Data are representative of 2 independent experiments (mean ± SEM); two-way ANOVA followed by Bonferroni’s multiple comparison test was used to evaluate significant differences: * p < 0.01 vs. 1 h Cy5/PLGA+ (A); * p < 0.001 vs. 8 h Cy5/PLGA+ (B).