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(A) Dissolution rate of MLX with buffer changes (pH 1.2, 6.8 and 7.4) for MLX raw material and 0.85–1.00 mm size diameter granules of CNM, CFS and CNM + CFS. (B) Higuchi kinetic model applied for MLX release from MLX raw material, multiparticulate colonic systems CNM + CFS, CFS and CNM. (C) First-order kinetic model applied for MLX release from MLX raw material, multiparticulate colonic systems CNM + CFS, CFS and CNM.
