(a) Results of mechanical testing when the fibrinogen concentration of the glue is varied, keeping the thrombin (200 units/mL), aprotinin (3000 Klu/mL), and calcium (40 μmol/mL) levels constant. (b) Results of mechanical testing when the thrombin concentration of the glue is regulated, keeping the fibrinogen (39 g/L), aprotinin (3000 Klu/mL), and calcium (40 μmol/mL) levels constant. (c) Results of mechanical testing when the factor XIII/fibrinogen ratio is varied, keeping the thrombin (200 units/mL), aprotinin (3000 KIu/mL) and calcium (40 μmol/mL) levels constant. All measurements reported in the plots are the mean p < 0.01, difference from control; Mann–Whitney U test. Data were compiled from [23].