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. 2022 Jul 19;23(14):7964. doi: 10.3390/ijms23147964

Figure 2.

Figure 2

Conservation and synteny between mouse and human LRI-E and LRI. (A)—Violin plots showing sequence conservation of hmsLRI-E, versus random shuffled genomic regions with similar GC content (**** p < 0.0001, Wilcoxon rank-sum test). PhastCons score over 100 vertebrates is reported. Lines span the first to third quartiles (Q1 to Q3), dots denote the median. (B) Ring chart with the fraction of hmsLRI-E (active on left and poised on right) overlapping exonic, intergenic, intronic or promoter regions in the human genome. (C)—Circos plot showing the genomic correspondences of enhancers involved in LRI between mouse and human. Mouse chromosomes are represented in blue (chr1-19, X), human chromosomes are in red (chr1-22, X).