Table 2.
Time (h) | Tangeretin (% of dose) | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
| ||||||||||||
Plasma | Heart | Lung | Liver | Spleen | Kidney | Stomach | Small intestine | Cecum | Colon | Rectum | Total | |
4 | 0.001 ± 0.000 | 0.002 ± 0.000 | 0.042 ± 0.021 | 0.030 ± 0.083 | 0.007 ± 0.005 | 0.120 ± 0.005 | 20.033 ± 3.203 | 3.097 ± 0.918 | 0.579 ± 0.226 | 0.081 ± 0.022 | 0.008 ± 0.006 | 24.265 ± 4.051 |
8 | 0.000 ± 0.000 | 0.003 ± 0.000 | 0.019 ± 0.001 | 0.010 ± 0.014 | 0.010 ± 0.006 | 0.116 ± 0.028 | 3.943 ± 1.512 | 0.593 ± 0.243 | 0.086 ± 0.066 | 0.048 ± 0.047 | 0.009 ± 0.002 | 4.930 ± 1.840 |
12 | 0.000 ± 0.000 | 0.001 ± 0.001 | 0.018 ± 0.007 | 0.008 ± 0.002 | 0.006 ± 0.002 | 0.067 ± 0.052 | 0.420 ± 0.256 | 0.746 ± 0.350 | 0.927 ± 0.164 | 0.544 ± 0.248 | 0.521 ± 0.110 | 3.333 ± 0.925 |
24 | N.D | N.D | N.D | N.D | N.D | N.D | 0.026 ± 0.013 | 0.059 ± 0.017 | 0.040 ± 0.018 | 0.031 ± 0.012 | 0.014 ± 0.001 | 0.170 ± 0.027 |
Data are expressed as mean ± SD (n = 3). N.D: not detected. Weight percentage of tangeretin (% of dose) = [The amount of tangeretin in the tissue (mg)/the amount of tangeretin by oral administration (mg)] × 100%. The amount of tangeretin by oral administration (mg) = 50 mg/kg bw × body weight of each rat.