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. 2017 Sep 22;26(2):849–857. doi: 10.1016/j.jfda.2017.08.003

Table 2.

Weight percentage of dosed tangeretin in rat tissues after oral administration of tangeretin.

Time (h) Tangeretin (% of dose)

Plasma Heart Lung Liver Spleen Kidney Stomach Small intestine Cecum Colon Rectum Total
4 0.001 ± 0.000 0.002 ± 0.000 0.042 ± 0.021 0.030 ± 0.083 0.007 ± 0.005 0.120 ± 0.005 20.033 ± 3.203 3.097 ± 0.918 0.579 ± 0.226 0.081 ± 0.022 0.008 ± 0.006 24.265 ± 4.051
8 0.000 ± 0.000 0.003 ± 0.000 0.019 ± 0.001 0.010 ± 0.014 0.010 ± 0.006 0.116 ± 0.028 3.943 ± 1.512 0.593 ± 0.243 0.086 ± 0.066 0.048 ± 0.047 0.009 ± 0.002 4.930 ± 1.840
12 0.000 ± 0.000 0.001 ± 0.001 0.018 ± 0.007 0.008 ± 0.002 0.006 ± 0.002 0.067 ± 0.052 0.420 ± 0.256 0.746 ± 0.350 0.927 ± 0.164 0.544 ± 0.248 0.521 ± 0.110 3.333 ± 0.925
24 N.D N.D N.D N.D N.D N.D 0.026 ± 0.013 0.059 ± 0.017 0.040 ± 0.018 0.031 ± 0.012 0.014 ± 0.001 0.170 ± 0.027

Data are expressed as mean ± SD (n = 3). N.D: not detected. Weight percentage of tangeretin (% of dose) = [The amount of tangeretin in the tissue (mg)/the amount of tangeretin by oral administration (mg)] × 100%. The amount of tangeretin by oral administration (mg) = 50 mg/kg bw × body weight of each rat.