Table 3.
Urinary and fecal excretion of tangeretin during each time interval after oral administration of tangeretin.
| Time (h) | Urine | Feces | ||
|---|---|---|---|---|
|
|
|
|||
| Conc. (μg/mL) | Amount (μg) | Conc. (μg/g) | Amount (μg) | |
| 0–4 | 0.0386 ± 0.0178 | 0.2691 ± 0.1678 | N.D | N.D |
| 4–8 | 0.0214 ± 0.0121 | 0.0778 ± 0.0429 | 2.40 ± 1.74 | 3.62 ± 3.11 |
| 8–12 | 0.0055 ± 0.0028 | 0.0298 ± 0.0131 | 243.16 ± 112.05 | 377.34 ± 298.82 |
| 12–24 | 0.0010 ± 0.0004 | 0.0152 ± 0.0057 | 184.74 ± 48.70 | 712.12 ± 157.71 |
| 24–36 | 0.0006 ± 0.0004 | 0.0061 ± 0.0042 | 26.86 ± 11.21 | 97.70 ± 37.16 |
| 36–48 | 0.0005 ± 0.0001 | 0.0083 ± 0.0025 | 1.36 ± 0.48 | 6.54 ± 3.09 |
| Total | – | 0.4062 ± 0.1987 | – | 1197.33 ± 307.43 |
| % of dosing | – | 0.0026 ± 0.0012 | – | 7.54 ± 1.89 |
Data are expressed as mean ± SD (n = 6). The given dose was 50 mg/kg. The amount of tangeretin by oral administration (mg) = 50 mg/kg bw × body weight of each rat.