Figure 7.

Luciferase reporter assay for the PGC-1α promoter. Cardiac myocytes were transduced with empty vector (Control) or a vector encoding NF-κB p65 subunit and PGC-1α promoter reporter and monitored for PGC-1α promoter activity in the absence and presence of trichostatin A (TSA, 10 μM). TSA alone did not affect PGC-1α promotor activity, whereas TSA in the presence of NF-κB p65 vector partially reversed the decrease in PGC-1α promotor activity by p65. * p < 0.05 or ** p < 0.01 versus indicated sample.