TABLE 1.
Study Population Characteristics
| All | mRS 0–2 | mRS 3–6 | ||
|---|---|---|---|---|
| n = 393 | n = 258 | n = 135 | p | |
| Age, median (IQR), yr | 73 (65–78) | 72 (64–78) | 75 (68–80) | <0.001 |
| Sex, males, n (%) | 215 (54.7) | 136 (52.7) | 79 (58.5) | 0.272 |
| Pre‐stroke mRS | ||||
| 0, n (%) | 324 (82.4) | 220 (85.3) | 104 (77.0) | 0.047 |
| 1, n (%) | 56 (14.2) | 33 (12.8) | 23 (17.0) | |
| 2, n (%) | 13 (3.3) | 5 (1.9) | 8 (5.9) | |
| Admission NIHSS, median (IQR) | 14 (10–20) | 12 (9–15) | 21 (17–23) | <0.001 |
| ASPECTS score, median (IQR) | 9 (8–10) | 9 (8–10) | 8 (7–10) | <0.001 |
| Occlusion site | ||||
| Cervical ICA, n (%) | 86 (21.9) | 44 (17.1) | 42 (31.1) | <0.001 |
| Terminal ICA, n (%) | 14 (3.6) | 4 (1.6) | 10 (7.4) | |
| MCA M1, n (%) | 266 (67.7) | 188 (72.9) | 78 (57.8) | |
| MCA M2, n (%) | 27 (6.9) | 22 (8.5) | 5 (3.7) | |
| r‐TPA before EVT, n (%) | 126 (32.1) | 88 (34.1) | 38 (28.1) | 0.229 |
| Time from onset to NCCT, median (IQR) minutes | 279 (118–333) | 281 (118–327) | 257 (116–354) | 0.961 |
| Time from NCCT to reperfusion, median (IQR), minutes | 124 (100–163) | 112 (96–138) | 151 (121–213) | <0.001 |
| Collateral score | ||||
| 0, n (%) | 14 (3.6) | 0 (0.0) | 14 (10.4) | <0.001 |
| 1, n (%) | 106 (27.0) | 17 (6.6) | 89 (65.9) | |
| 2, n (%) | 155 (39.4) | 134 (51.9) | 21 (15.6) | |
| 3, n (%) | 118 (30.0) | 107 (41.5) | 11 (8.1) | |
| mTICI score | ||||
| 0, n (%) | 34 (8.7) | 8 (3.1) | 26 (19.3) | <0.001 |
| 1, n (%) | 24 (6.1) | 1 (0.4) | 21 (17.0) | |
| 2a, n (%) | 37 (9.4) | 4 (1.6) | 33 (24.4) | |
| 2b, n (%) | 63 (16.0) | 40 (15.5) | 23 (17.0) | |
| 3, n (%) | 235 (59.8) | 205 (79.5) | 30 (22.2) | |
| Tmax >9.5 seconds volume, median (IQR), ml | 102 (55–160) | 69 (41–112) | 175 (121–218) | <0.001 |
| Tmax >16 seconds volume, median (IQR), ml | 30 (11–77) | 20 (6–35) | 93 (50–110) | <0.001 |
| Tmax mismatch volume, median (IQR), ml | 56 (35–91) | 48 (29–73) | 81 (51–117) | <0.001 |
| Tmax mismatch ratio, median | 2.7 (2.0–5.2) | 3.7 (2.4–6.7) | 2.0 (1.6–2.5) | <0.001 |
| Final infarct volume, median (IQR), ml | 29 (10–92) | 16 (5–29) | 103 (87–135) | <0.001 |
| Hemorrhagic transformation ECASS II | ||||
| None, n (%) | 252 (64.1) | 195 (75.6) | 57 (42.2) | <0.001 |
| HT1, n (%) | 63 (16.0) | 41 (15.9) | 22 (16.3) | |
| HT2, n (%) | 32 (8.1) | 11 (4.3) | 21 (15.6) | |
| PH1, n (%) | 20 (5.1) | 7 (2.7) | 13 (9.6) | |
| PH2, n (%) | 26 (6.6) | 4 (1.6) | 22 (16.3) | |
| sICH, n (%) | 39 (9.9) | 7 (2.7) | 32 (23.7) | <0.001 |
| Any hemorrhagic transformation, n (%) | 141 (35.8) | 78 (57.8) | 63 (24.4) | <0.001 |
ASPECTS = Alberta Stroke Program Early Computed Tomography Score; DSA = digital subtraction angiography; ECASS = European Cooperative Acute Stroke Study; EVT = endovascular treatment; HI1 = hemorrhagic infarction type 1; HI2 = hemorrhagic infarction type 2; ICA = internal carotid artery; IQR = interquartile range; MCA = middle cerebral artery; mRS = modified Rankin Scale; mTICI = modified treatment in cerebral infarction score; NCCT = non‐contrast computed tomography; NIHSS = National Institute of Health Stroke Scale; PH1 = parenchymal hemorrhage type 1; PH2 = parenchymal hemorrhage type 2; r‐TPA = recombinant tissue plasminogen activator; sICH = symptomatic intracerebral hemorrhage; Tmax = time to maximum concentration.