TABLE 3.
Multivariate logistic regression model exploring the association between stratified delay to surgery and resectability, adjusting for patient and disease factors
| Non‐resectable (n = 297) | Resectable (n = 3669) | OR (univariable) | OR (multivariable) | ||
|---|---|---|---|---|---|
| Delay | 0–4 weeks | 193 (8.2) | 2154 (91.8) | – | – |
| 5–8 weeks | 66 (6.5) | 955 (93.5) | 1.30 (0.98–1.74, P = 0.079) | 1.16 (0.86–1.59, P = 0.344) | |
| 9–12 weeks | 19 (5.3) | 338 (94.7) | 1.59 (1.01–2.67, P = 0.060) | 1.40 (0.85–2.41, P = 0.206) | |
| >12 weeks | 19 (7.9) | 222 (92.1) | 1.05 (0.66–1.76, P = 0.855) | 1.03 (0.62–1.80, P = 0.920) | |
| Site | Colon | 200 (6.6) | 2846 (93.4) | – | – |
| Rectum | 97 (10.5) | 823 (89.5) | 0.60 (0.46–0.77, P < 0.001) | 0.51 (0.38–0.68, P < 0.001) | |
| Age | <70 | 158 (7.9) | 1850 (92.1) | – | – |
| ≥70 | 139 (7.1) | 1819 (92.9) | 1.12 (0.88–1.42, P = 0.358) | 1.03 (0.78–1.36, P = 0.828) | |
| Sex | Female | 127 (7.3) | 1604 (92.7) | – | – |
| Male | 170 (7.6) | 2065 (92.4) | 0.96 (0.76–1.22, P = 0.749) | 0.91 (0.70–1.18, P = 0.491) | |
| ASA grade | 1–2 | 187 (7.1) | 2437 (92.9) | – | – |
| 3–5 | 110 (8.2) | 1232 (91.8) | 0.86 (0.67–1.10, P = 0.226) | 0.99 (0.73–1.36, P = 0.964) | |
| ECOG grade | 0 | 129 (6.4) | 1874 (93.6) | – | – |
| 1–2 | 144 (7.9) | 1690 (92.1) | 0.81 (0.63–1.03, P = 0.090) | 0.74 (0.55–0.98, P = 0.039) | |
| 3–4 | 24 (18.6) | 105 (81.4) | 0.30 (0.19–0.50, P < 0.001) | 0.29 (0.17–0.53, P < 0.001) | |
| RCRI grade | 1–2 | 278 (7.6) | 3387 (92.4) | – | – |
| ≥3 | 19 (6.3) | 282 (93.7) | 1.22 (0.77–2.03, P = 0.421) | 1.18 (0.71–2.08, P = 0.544) | |
| Stage group | Stage I | 39 (2.7) | 1418 (97.3) | – | – |
| Stage II | 35 (4.0) | 838 (96.0) | 0.66 (0.41–1.05, P = 0.078) | 0.65 (0.40–1.03, P = 0.066) | |
| Stage III | 102 (7.8) | 1205 (92.2) | 0.32 (0.22–0.47, P < 0.001) | 0.34 (0.23–0.49, P < 0.001) | |
| Stage IV | 121 (36.8) | 208 (63.2) | 0.05 (0.03–0.07, P < 0.001) | 0.05 (0.03–0.07, P < 0.001) | |
Notes: Number in dataframe 3966, number in model 3966, missing 0, Akaike information criterion 1790.1, C statistic 0.776. Delay was measured from decision to treat to surgery. Data reported as odds ratio (95% confidence interval, P value). OR >1 means higher odds of resectability for delayed patients, OR <1 means lower odds of resectability for delayed patients.
Abbreviations: ASA, American Society of Anesthesiologists classification; ECOG, Eastern Cooperative Oncology Group; RCRI, Revised Cardiac Risk Index.