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. 2022 Mar 31;162(1):60–79. doi: 10.1111/jnc.15607

FIGURE 2.

FIGURE 2

The 5‐H T2A receptor impacts social adaptation processing via the mPFC during the process of information integration. The 5‐HT2A receptor plays a key role in the processing and integration of social information via its effect on the mPFC. It is proposed that stimulation of 5‐HT2A receptor induces alterations in self‐relevance processing that affects computation of value that reflects expected reward signals for subsequent choice of behavior in the process of value‐based decision‐making. The 5‐HT system is therefore suggested to modulate the process of liking during value‐based decision‐making that contributes to the forming of subjectivity in the valuation signals, therefore crucial for learning and updating processes of representations. mPFC, medial prefrontal cortex; PE, prediction error