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A) Structure of the μOR‐Gi complex bound to PZM21 colored by subunit. Green, μOR; orange, PZM21; gold, Gαi; cyan, Gβ; purple Gγ; gray scFv16. B) View of PZM21 in the binding pocket. PZM21 forms polar contacts to D1473.32 and Y3267.43 and the phenol group is near H2976.52 suggesting that PZM21 forms a water‐mediated interaction with H2976.52, as observed in previous structures of the μOR. C) Surface presentation of the thiophene group of PZM21 in the lipophilic vestibule of the μOR.
