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A) Structure of the μOR‐Gi complex bound to FH210 colored by subunit. Blue, μOR; beige, FH210; gold, Gαi; cyan, Gβ; purple Gγ; gray scFv16. B) View of FH210 in the binding pocket. Blue, μOR; beige, FH210. FH210 forms polar contacts with D1473.32 and Y3267.43 and shows proximity of the phenol group to H2976.52 suggesting that the ligand forms a water mediated interaction to H2976.52. C) Surface representation of the naphthyl group of FH210 in the lipophilic vestibule of the μOR.
