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. 2022 Jul 12;11(14):2180. doi: 10.3390/cells11142180

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Inflammasome production and ASC-speck formation. Representative images of Nod-like receptor protein 3 (NLRP3) expression and apoptosis-associated speck-like-protein containing CARD (ASC)-speck formation. ASC-speck (a) and ASC-diffuse (b) images were obtained by AMNIS FlowSight-merged (Ch02/03) NLRP3-FITC (Ch02) and ASC-PE (Ch03) fluorescences; analysis of ASC-speck and its co-localization with NLRP3 was performed by IDEAS software, which provides tools to evaluate image regions (masks) and perform calculations (features). The percentage of ASC-speck-positive cells is shown in panel (c). Statistical significance is shown.