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. 2022 Jul 26;39(9):2191–2201. doi: 10.1007/s11095-022-03340-9

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Lung PK and safety profile after single-dose inhalation of HB27 antibody in cynomolgus monkeys. The HB27 antibody concentrations (a) and cytokine levels (b) in ELF were measured at 24, 48 and 72 h after administration. Dashed line represents PRNT₉₀ (1.28 μg/mL) of HB27 against authentic SARS-CoV-2. The data are shown as Mean ± SD. HB27 antibody in serum could not be quantified below the lower limit of detection (0.39 μg/mL).