Table 2.
Adjusted dose of a single aerosol inhalation of theoretical 10 mg/kg HB27 liquid formulation in cynomolgus monkeys
| Time | Animal ID | RMV (mL/min) |
BW (kg) |
TDD (mg/kg) |
DLD (mg/kg) |
LW (g) |
LD (mg/g) |
|---|---|---|---|---|---|---|---|
| 24 h | 1# | 2112.5 | 2.8 | 4.25 | 0.42 | 14.783 | 0.08 |
| 5# | 2527.6 | 5.0 | 3.86 | 0.39 | 26.157 | 0.07 | |
| 6# | 1890.6 | 4.6 | 3.64 | 0.36 | 20.825 | 0.08 | |
| Mean | 2176.9 | 4.1 | 3.92 | 0.39 | 20.588 | 0.08 | |
| SD | 323.3 | 1.2 | 0.31 | 0.03 | 5.691 | 0.01 | |
| 48 h | 2# | 1221.7 | 2.9 | 2.76 | 0.28 | 20.271 | 0.04 |
| 3# | 905.4 | 3.1 | 2.28 | 0.23 | 17.214 | 0.04 | |
| 7# | 4710 | 4.6 | 10.61 | 1.06 | 23.471 | 0.21 | |
| Mean | 2279.0 | 3.5 | 5.22 | 0.52 | 20.319 | 0.10 | |
| SD | 2111.2 | 0.9 | 4.68 | 0.47 | 3.129 | 0.10 | |
| 72 h | 4# | 1810.3 | 3.2 | 2.74 | 0.27 | 16.313 | 0.05 |
| 8# | 3908.8 | 4.4 | 5.78 | 0.58 | 23.001 | 0.11 | |
| 9# | 3628.7 | 5.5 | 5.83 | 0.58 | 24.397 | 0.13 | |
| Mean | 3115.9 | 4.4 | 4.78 | 0.48 | 21.237 | 0.10 | |
| SD | 1139.4 | 1.2 | 1.77 | 0.18 | 4.321 | 0.04 |