. 2022 Jul 19;23(14):7929. doi: 10.3390/ijms23147929

Table 1.

Biological activity of CBG and its derivatives.

	CBG	CBGA	VCE-003	VCE-003.2
Activity Area
Receptors	Agonist: CB1, CB2, PPARγ, TRPA1, TRPV1, TRPV2, TRPV3, TRPV4, α2-adenoceptors	Agonist: CB1, CB2, PPARγ, TRPA1, TRPV1, TRPV2, TRPV3, TRPV4	Agonist: CB1, CB2, PPARγ	Agonist: CB1, CB2, PPARγ
Receptors	Antagonist: TRPM8, 5-HT_1A	Antagonist: TRPM8	Agonist: CB1, CB2, PPARγ	Agonist: CB1, CB2, PPARγ
Endocannabinoid system enzymes	Inhibition: FAAH, DAGLα, MAGL	Inhibition: FAAH, MAGL, DAGLα	Inhibition: MAGL	Inhibition: FAH, MAGL
Redox status and inflammation	Downregulation: TNFα, NFκB, IL-1ß, IL-6, INF-γ, PGE₂	Downregulation: TNFα, NFκB, IL-1ß, IL-6, INF-γ, PGE₂	Downregulation: TNFα, IL-1ß, IL-2, IL-6, IL-17, INF-γ, PGE₂	Downregulation: TNFα, NFκB, IL-1ß, IL-6, PGE₂, Caspase 3
	Inhibition: iNOS, COX-1, COX-2, PLA2	Inhibition: iNOS, COX-1, COX-2, PLA2	Inhibition: iNOS,	Inhibition: iNOS, COX-2
	Upregulation: Catalase, SOD-1	Inhibition: iNOS, COX-1, COX-2, PLA2	Upregulation: Nrf2	Inhibition: iNOS, COX-2
Biological activity
	antioxidant anti-inflammatory antibacterial neuromodulatory neuroprotective	antioxidant antibacterial neuromodulatory neuroprotective	anti-inflammatory neuromodulatory neuroprotective	anti-inflammatory neuromodulatory neuroprotective
References
	[21,57,58,59,60,61,62,63,64]	[21,49,58,59,62,65]	[57,64,66,67,68,69,70]	[57,63,64,66,68]

Abbreviation: CBG—cannabigerol; CBGA—cannabigerolic acid; VCE-003—cannabigerol quinone; VCE-003.2—second-generation cannabigerol quinone derivative.