Scheme 2.
Reagents and conditions: (a) Suberic acid, NMI, TCFH, ACN, room temperature, 24 h; (b) (1) VHL ligand 40 (see S3 in Supplementary Material), DIPEA, HATU, DMF, 0 °C, 2 h; (2) 1 M HCl, THF/MeOH, US, 0 °C, 2 h.
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