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. 2022 Jul 7;23(14):7535. doi: 10.3390/ijms23147535

Scheme 5.

Scheme 5

Reagents and conditions: (a) Pd/C (5%), H2, EtOAc: THF (1:1); (b) (1) E3 ligase ligand-linker-NH2 53, 56, 59/HyT-linker-NH2 57 (see Scheme S4.3 in Supplementary Materials), DIPEA, HATU, DMF, room temperature; (2) 2 M HCl, THF, room temperature.